Blocking Thrombin Significantly Ameliorates Experimental Autoimmune Neuritis
نویسندگان
چکیده
منابع مشابه
Human immunoglobulin ameliorates rat experimental autoimmune neuritis.
Human immunoglobulin is an effective treatment for Guillain-Barré syndrome, although the mechanism of action is not understood. We have investigated the effect of human immunoglobulin in an animal model of Guillain-Barré syndrome, namely experimental autoimmune neuritis (EAN), induced in Lewis rats by immunization with bovine spinal root myelin. Human immunoglobulin administered intraperitoneal...
متن کاملBlocking GluR2–GAPDH ameliorates experimental autoimmune encephalomyelitis
OBJECTIVE Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. The pathophysiological mechanism of MS remains largely unknown and no cure is available. Current clinical treatments for MS modulate the immune system, with the rationale that autoimmunity is at the core of MS pathophysiology. METHODS Experimental autoimmune encephalitis (EAE) was induced in m...
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Experimental autoimmune neuritis (EAN) is a cluster of differentiation 4+ T helper 1 cell-mediated inflammatory demyelinating disease of the peripheral nervous system and serves as a useful animal model for Guillain‑Barré syndrome. Triggering receptor expressed on myeloid cells‑1 (TREM‑1) is an important receptor involved in sepsis and the innate inflammatory response. Linear plasmid 17 (LP 17)...
متن کاملCorrection: Dimethyl Fumarate Ameliorates Lewis Rat Experimental Autoimmune Neuritis and Mediates Axonal Protection
Fig 2 and Fig 4 are swapped. The image in Fig 2 should be the image in Fig 4 and the image in Fig 4 should be the image in Fig 2. The captions remain unchanged. The publisher apologizes for the error. Please see the corrected Fig 2 and Fig 4 here. open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reprod...
متن کاملQuinpramine Ameliorates Rat Experimental Autoimmune Neuritis and Redistributes MHC Class II Molecules
Activation of inflammatory cells is central to the pathogenesis of autoimmune demyelinating diseases of the peripheral nervous system. The novel chimeric compound quinpramine--generated from imipramine and quinacrine--redistributes cholesterol rich membrane domains to intracellular compartments. We studied the immunological and clinical effects of quinpramine in myelin homogenate induced Lewis ...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2019
ISSN: 1664-2295
DOI: 10.3389/fneur.2018.01139